NCT00199407, A Study of Istradefylline (KW-6002) for the Treatment of Parkinson's Disease in Patients Taking Levodopa. Istradefylline (DB11757).

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In: Journal of Neurochemistry, Vol. 84, No. 6, 2003, p. 1398-1410. Research output: Contribution to journal › Article 2013-11-21 · Tokyo, Japan, November 21, 2013 --- Kyowa Hakko Kirin Co., Ltd. (Tokyo: 4151, President and CEO: Nobuo Hanai, "Kyowa Hakko Kirin") today announced the initiation of a global phase 3 clinical trial of istradefylline (generic name / code name: KW-6002), for Parkinson's disease. This global clinical trial is being conducted under a Special Protocol Assessment (SPA) agreement with the US Food and Patients with Parkinson's disease who completed the prior double-blind study 6002-009 are eligible to enter into this long-term study. The purpose of this study is to evaluate the safety and efficacy of KW-6002 administered long-term in patients with advanced Parkinson's disease treated with levodopa.

These results are the first to show directly that orally administered KW-6002 is distributed selectively to the striatum and that it modulates the activity of striatopallidal enkephalin-containing neurons but not striatonigral substance P-containing neurons. Istradefylline (KW-6002) is a selective antagonist at the A 2A receptor.It has been found to be useful in the treatment of Parkinson’s disease. Istradefylline reduces dyskinesia resulting from long-term treatment with classical antiparkinson drugs such as levodopa. KW 6002. January 2011; DOI: 10.1016/B978-008055232-3.63096-X. Authors: Michael Williams. Request full-text PDF. To read the full-text of this research, you can request a copy directly from the author.

doi: 10.1007/s00213-014-3454-0. Epub 2014 Feb 2.

Patients with Parkinson's disease who completed the prior double-blind study 6002-009 are eligible to enter into this long-term study. The purpose of this study is to evaluate the safety and efficacy of KW-6002 administered long-term in patients with advanced Parkinson's disease treated with levodopa.

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KW-6002 and Biogen-34 exhibited the highest selectivity for A2A vs A1 (human and rat), respectively. The pharmacokinetic profiles of antagonists were evaluated in vivo in rats. DMPX and KW-6002

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Abstract. We have examined the ability of KW-6002, an adenosine A2a antagonist, to modulate the dyskinetic effects of L-DOPA in. 6-hydroxydopamine- lesioned

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Tokyo, Japan, March 1, 2019 --- Kyowa Hakko Kirin Co., Ltd. (Tokyo: 4151, President and COO: Masashi Miyamoto, "Kyowa Kirin") announced it has resubmitted a New Drug Application to the Food and Drug Administration (FDA) for Istradefylline (KW-6002), an investigational selective adenosine A2A receptor antagonist, for use as adjunctive treatment to levodopa/carbidopa in adult patients with

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